Christian was an important early performer on the electric guitar and a key figure in the development of bebop and cool jazz. He gained national exposure as a member of the Benny Goodman Sextet and Orchestra from August 1939 to June 1941. His single-string technique, combined with amplification, helped bring the guitar out of the rhythm section and into the forefront as a solo instrument. For this, he is often credited with leading to the development of the lead guitar role in musical ensembles and bands.
Christian's influence reached beyond jazz and swing. In 1990, he was inducted into the Rock and Roll Hall of Fame in the category Early Influence.
In 2006 Oklahoma City renamed a street in its Bricktown entertainment district "Charlie Christian Avenue" (Christian was raised in Oklahoma City and was one of many musicians who jammed along the city's "Deep Deuce" section on N.E. Second Street).